Thiophene derivatives with antisecretory activity
US4537968A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 21, 1983 |
| Grant date | Aug 27, 1985 |
| Priority date | — |
| Expiry date | Dec 21, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula: ##STR1## wherein A is ##STR2## R is mono- or dihalo, amino, nitro, cyano, hydroxy, trifluoromethyl, mercapto, lower alkyl, lower alkoxy, alkanoyl, lower cycloalkyl, carboxy, alkoxycarbonyl, mono- or di-lower alkyl substituted amino, alkanoylamino, lower alkyl thio, loweralkyl-sulfonyl, sulfamoyl, lower alkyl substituted sulfamoyl, phenyl or phenyl substituted with halo, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, amino, cyano or nitro; PA0 X and Y are each, independently, hydrogen or ##STR3## wherein R.sup.1 is hydrogen or lower alkyl; PA0 R.sup.2 is hydrogen or lower alkyl; or PA0 R.sup.1 and R.sup.2 taken together form a heterocyclic moiety selected from 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 1-octahydroazocinyl, 3-thiazolidinyl, 4-morpholinyl or 4-thiomorpholinyl, with the proviso that one of X and Y is always hydrogen; PA0 n is 1-4; and the pharmacologically acceptable salts thereof, which are intermediates in preparing H.sub.2 receptor antagonists and which also have antisecretory/antiulcer activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.