1-Phenylindazol-3-one compounds

US4537975A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Henning Heinemann · Hannover, DE
• Daniel Jasserand · Paris, FR
• Wolfgang Milkowski
• Dimitri Yavordios · Belleville, FR
• Horst Zeugner

Key dates

• Filing date: Dec 22, 1983
• Grant date: Aug 27, 1985
• Expiry date: Dec 22, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds corresponding to the formula: ##STR1## wherein R.sub.1 and R.sub.3 each represent hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; R.sub.2 and R.sub.4 each represent hydrogen, halogen, lower alkyl or lower alkoxy; Z represents an alkylene radical with 2 to 6 carbon atoms and Y" is halogen, hydroxyl, lower alkanesulphonyl, benzenesulphonyl, or lower alkyl or halogen substituted benzenesulphonyl, and acid addition salts thereof, with the proviso the Y" is other than chlorine if R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each are hydrogen and Z is ethylene or propylene. The claimed compounds are useful intermediates in the synthesis of 1-phenyl-2-[(4-substituted piperazinyl) alkyl]-1,2-dihydro-3H-indazol-3-ones which exhibit antiallergic activity.