(2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof
US4539313A · kind A · utility
4Cited by
7References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 27, 1984 |
| Grant date | Sep 3, 1985 |
| Priority date | — |
| Expiry date | Apr 27, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
3'-deoxyadenosine 5'-triphosphate is oligomerized to form (2'-5')-oligo (3'-deoxyadenylate) by incubation with adenosine triphosphate: (2'-5')-oligo adenosine adenyl transferase, in the presence of an inert support carrying a double stranded polynucleotide. The (2'-5')-oligo (3'-deoxyadenylate) is digested with a suitable phosphatase to remove the terminal phosphate groups. The thus produced corresponding 3'-deoxyadenosine compound is an anti-viral material effective against Herpes simplex infection and effective in inhibiting the transformation of cells infected with Epstein Barr virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.