Substituted pyrimidin-2-ones and the salts thereof

US4539324A · kind A · utility

Assignee

• Nyegaard & Co. A/S · NO

Inventors

• Tore Benneche · Oslo, NO
• Per Strande · Oslo, NO
• Kjell Undheim · Oslo, NO

Key dates

• Filing date: Feb 24, 1983
• Grant date: Sep 3, 1985
• Expiry date: Feb 24, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the general formula: ##STR1## wherein X represents halogen or trifluoromethyl; PA0 R.sup.1 and R.sup.2, independently represent hydrogen or lower alkyl; PA0 R.sup.3, R.sup.4 and R.sup.5, which may be the same or different, each represent hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower alkanoyl, lower alkenoyl, C.sub.7-16 aralkyl or C.sub.6-10 aryl or a 5-9 membered unsaturated or aromatic heterocyclic ring; one or both of R.sup.4 and R.sup.5 may also represent aroyl groups; PA0 Z represents an oxygen atom or a sulfur atom or oxide thereof or a group NR.sup.6 (wherein R.sup.6 is as defined for R hereinafter or represents the group COR.sup.7 in which R.sup.7 represents hydrogen or optionally substituted aryl, heterocyclic, aralkyl, lower alkyl or lower alkoxy group; and PA0 R represents a C.sub.6-10 carbocyclic aromatic group or a heterocyclic group containing a 5-9 membered unsaturated or aromatic heterocyclic ring which ring contains one or more heteroatoms selected from O, N and S and optionally carries a fused ring which carbocyclic or heterocyclic group may carry one or more C.sub.1-4 alkyl or phenyl groups said groups being optionally substituted; and wh…