7'-Trifluoromethyl-spiro[imidazolidine-4,3'-indoline]-2,2',5-triones as aldose reductase inhibitors
US4539329A · kind A · utility
0Cited by
3References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 6, 1983 |
| Grant date | Sep 3, 1985 |
| Priority date | — |
| Expiry date | May 6, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns novel trifluoromethyl derivatives of 1'-halogenobenzyl-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione (I), their pharmaceutically acceptable salts, and non-toxic, biodegradable precursors thereof. The derivatives are potent inhibitors of the enzyme aldose reductase and are useful in treating or preventing certain complications of diabetes. The invention also provides pharmaceutical compositions and processes for the manufacture of the derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.