2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists
US4539332A · kind A · utility
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9Claims
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Key dates
| Filing date | Nov 14, 1983 |
| Grant date | Sep 3, 1985 |
| Priority date | — |
| Expiry date | Nov 14, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Analogs of 2,5-Diaryl tetrahydrofurans which were substituted or unsubstituted at 3,4-positions were prepared. These compounds are found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.