3-Nitro-5-amide-1,4-dihydropyridines with positive inotropic activity

US4540684A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Jurgen Stoltefuss · Haan, DE
• Gerhard Franckowiak · Wuppertal, DE
• Horst Boshagen · Haan, DE
• Siegfried Goldmann · Wuppertal, DE
• Matthias Schramm · Cologne, DE
• Gunter Thomas · Arese, IT
• Rainer Gross · Wuppertal, DE

Key dates

• Filing date: May 18, 1984
• Grant date: Sep 10, 1985
• Expiry date: May 18, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A 1,4-dihydropyridine derivative of the formula ##STR1## in which R and R.sub.1 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 to C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, trifluoromethyl, ##STR2## X is oxygen or sulphur, R.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, trifluoromethyl, amino or nitro, and PA1 R.sub.2 and R.sub.3 each independently is hydrogen, a C.sub.1 -C.sub.10 -alkyl, C.sub.2 -C.sub.10 -alkenyl or C.sub.3 -C.sub.10 -alkinyl radical which is optionally substituted by halogen, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, mono- and di-C.sub.1 -C.sub.4 -alkylamino, carbo-C.sub.1 -C.sub.6 -alkoxy and/or nitro, a C.sub.3 to C.sub.6 -membered cycloalkyl radical, a phenyl radical which is optionally substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, amino and/or nitro, or a phenyl-C.sub.1 -C.sub.3 -alkyl radical, or a carbohydrate radical which is optionally bonded via a C.sub.1 -C.sub.8 -alkyl chain to the amide nitrogen atom or a pharmaceutically acceptable acid addition salt thereof, which improves the contractility of the heart, raises th…