Preparation of 2-chloro-3-cyano-quinolines
US4540786A · kind A · utility
4Cited by
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8Claims
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Key dates
| Filing date | Aug 22, 1983 |
| Grant date | Sep 10, 1985 |
| Priority date | — |
| Expiry date | Aug 22, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/54
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process is described for introducing nitrile groups to compounds susceptible to Vilsmeier formylation via two sequential reactions in a single reaction medium. In the first reaction, the susceptible compound is reacted with a Vilsmeier reagent in the presence of phosphorus oxychloride. In the second reaction, a hydroxylamine salt is introduced to the medium in the presence of at least an equivalent amount of phosphorus oxychloride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.