Circulation-active novel chromone-and thiochromone-substituted 1,4-dihydropyridines

US4540789A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Siegfried Goldmann · Wuppertal, DE
• Gerhard Franckowiak · Wuppertal, DE
• Matthias Schramm · Cologne, DE
• Gunter Thomas · Arese, IT
• Rainer Gross · Wuppertal, DE

Key dates

• Filing date: Mar 14, 1984
• Grant date: Sep 10, 1985
• Expiry date: Mar 14, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 can be hydrogen or various halogen or organic radicals, PA0 R.sup.4 is an optionally substituted hydrocarbon radical, PA0 A is a direct bond, an alkylene chain with 1 to 20 C atoms or an alkenylene chain with 2 to 20 atoms, the chains being optionally interrupted by O or S, PA0 X is O or S and PA0 Y is a direct bond, O, S, -NH- or -N- alkyl with 1 to 8 C atoms, or a pharmaceutically acceptable salt thereof, are useful as cardiotonic agents for improving heart contractility, antihypotonic agents, for lowering the blood sugar level, for detumescing mucous membranes and for influencing the salt and liquid balance.