Single-vessel process for preparing ring-substituted n-alkylanilines

US4540816A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Karl Sommer · Palzing, DE
• Rudolf Schickfluss

Key dates

• Filing date: May 10, 1984
• Grant date: Sep 10, 1985
• Expiry date: May 10, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C231/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for preparing ring-substituted N-alkylanilines of the formula (1) ##STR1## in which R.sub.1 and R.sub.2 each denote methyl or ethyl, in a single vessel, which comprises acylating m-nitroaniline in an excess of an aliphatic carbonyl compound of the formula (2) ##STR2## in which R.sub.1 is as defined above, with an acylating agent which contains the --CO--R.sub.2 acyl radical--which is transferred-- and reductively alkylating the resulting compound of the formula (3) ##STR3## in which R.sub.2 is as defined above, at temperatures of 120.degree.-160.degree. C. under a hydrogen pressure of 20-150 bar without intermediate isolation through the presence of an acid reaction promoter and of a nickel catalyst.