Process for the preparation of 5-amino-2,4-dimethylacetanilide

US4540817A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Horst Behre · Odenthal, DE
• Heinz U. Blank · Odenthal, DE
• Alfred Seyberlich · Leverkusen, DE
• Ferdinand Hagedorn · Leverkusen, DE

Key dates

• Filing date: Jul 25, 1983
• Grant date: Sep 10, 1985
• Expiry date: Jul 25, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C231/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of 5-amino-2,4-dimethylacetanilide by reduction of 5-nitro-2,4-dimethylacetanilide with hydrogen is disclosed characterized in that a crude mixture containing 5-nitro-2,4-dimethylacetanilide in admixture with at least one of its position isomers is hydrogenated in a water-miscible organic solvent which optionally contains water. The 5-amino-2,4-dimethylacetanilide is separated off from the reaction mixture by means of crystallization employing a mixture of water-miscible organic solvent and water.