4-Amino-benzo[b]pyran-3-ol derivatives
US4542149A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 6, 1983 |
| Grant date | Sep 17, 1985 |
| Priority date | — |
| Expiry date | Apr 6, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/70
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Anti-hypertensive compounds of formula (I): ##STR1## wherein: one of R.sub.1 and R.sub.2 is nitro, cyano or C.sub.1-3 alkylcarbonyl, and the other is methoxy or amino optionally substituted by one or two C.sub.1-6 alkyl or by C.sub.2-7 alkanoyl; PA0 one of R.sub.3 and R.sub.4 is hydrogen or C.sub.1-4 alkyl and the other is C.sub.1-4 alkyl, or R.sub.3 and R.sub.4 together with the carbon atom to which they are attached are C.sub.3-6 spiroalkyl; PA0 R.sub.5 is hydrogen, C.sub.1-3 alkyl or C.sub.1-8 acyl; and PA0 n is 1 or 2; the lactam group being trans to the OR.sub.5 group; or, when the other of R.sub.1 and R.sub.2 is amino, a pharmaceutically acceptable salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.