Acid-cleavable compound
US4542225A · kind A · utility
43Cited by
6References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 29, 1984 |
| Grant date | Sep 17, 1985 |
| Priority date | — |
| Expiry date | Aug 29, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Amino-sulfhydryl cross-linking reagents that are cleavable under mildly acidic conditions are disclosed. Also disclosed are methods of making the cross-linkers, as well as methods of using the cross-linkers, e.g., to deliver a biologically active substance across the membranes of selected cells in a heterogeneous cell population; once inside the cell the active substance is released, intact, by the transient, mild acidity of certain cell structures. Finally, a method of characterizing complex multi-chain protein structures is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.