Process for preparing biaryl compounds via coupling of an arylamine with an arene
US4542233A · kind A · utility
4Cited by
5References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 20, 1983 |
| Grant date | Sep 17, 1985 |
| Priority date | — |
| Expiry date | Jul 20, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C201/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene in the presence of a nitrite, an acid and copper metal or a derivative thereof; the improvement is consisting in adding to the reaction mixture a trialkylorthoformate. The process may be used for preparing drugs such as Flurbiprofen and Xenbucin or intermediate compounds particularly useful for preparing Flurbiprofen, Flufenisal, Chlordimorin, Xenbucin, Xenysalate, Xenyhexenic acid and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.