Bis(2,2-dimethyl-1-aziridinyl)phosphinic amides for use in the treatment of tumors

US4544501A · kind A · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Thomas J. Bardos · Snyder, US
• Michael E. Perlman · Old Saybrook, US
• Joan E. MacDiarmid · Amherst, US

Key dates

• Filing date: Apr 12, 1983
• Grant date: Oct 1, 1985
• Expiry date: Apr 12, 2003

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel bis(2,2-dimethyl-1-aziridinyl)phosphinic amide antineoplastic agents are disclosed of the formula: ##STR1## wherein R and R' are each, independently, hydrogen, alkyl, substituted alkyl, phenyl and substituted phenyl and, Z is oxygen or sulfur.