1'-Substituted-spiro[oxazolidine-5-3'-indoline]-2,2', 4-trione derivatives
US4544662A · kind A · utility
3Cited by
2References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 6, 1983 |
| Grant date | Oct 1, 1985 |
| Priority date | — |
| Expiry date | May 6, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides novel spiro[oxazolidine-5,3'-indoline]-2,2',4-triones of formula I bearing substituted benzyl or cinnamyl on the indoline nitrogen, together with salts and non-toxic, biodegradable precursors thereof. The compounds are potent inhibitors of the enzyme aldose reductase and are useful in treating or preventing certain diabetic complications. The invention also provides pharmaceutical compositions containing, and processes for the manufacture of, the compounds of formula I and their salts and derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.