Fabrication of living blood vessels and glandular tissues
US4546500A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 26, 1982 |
| Grant date | Oct 15, 1985 |
| Priority date | — |
| Expiry date | Feb 26, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/921
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method and apparatus for producing a vessel-equivalent prosthesis is described. A contractile agent such as fibroblast cells, smooth muscle cells or platelets is incorporated into a collagen lattice and contracts the lattice axially around an inner core. After the structure has set, additional layers may be formed in an ordered manner depending on the intended function of the prosthesis. Alternatively, all the layers may be formed concurrently. A plastic mesh sleeve is sandwiched between layers or embedded within the smooth muscle cell layer to reinforce the structure and provide sufficient elasticity to withstand intravascular pressure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.