Detecting rheumatoid factor with synthetic particles having immune complexes thereon
US4547466A · kind A · utility
8Cited by
5References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 1, 1983 |
| Grant date | Oct 15, 1985 |
| Priority date | — |
| Expiry date | Jun 1, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/808
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A suspension of particles such as carboxylated polystyrene latex particles are coated (as by carbodiimide coupling) with an antigen (such as chemically modified Bovine Serum Albumin). The antigen-coated particles are incubated with a gamma-globulin to the antigen (such as can be produced by immunizing rabbits) under non-agglutinating conditions. The particles having antigen/gamma-globulin immune complexes are recovered and resuspended to form a diagnostic reagent which agglutinates when mixed with human serum containing Rheumatoid Factor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.