Crosslinked, porous polymers for controlled drug delivery
US4548990A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 15, 1983 |
| Grant date | Oct 22, 1985 |
| Priority date | — |
| Expiry date | Aug 15, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1635
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A controlled-release, drug-delivery composition which comprises (A) a crosslinked copolymer, capable of swelling in ethanol to give a swollen copolymer containing at least 40% by weight of ethanol, and capable of swelling in water to give a swollen copolymer containing no more than 20% by weight of water, where the swelling ratio (% ethanol: % water) is 2:1 to 22:1, which comprises the copolymerization product of (a) 50 to 99% by weight of said copolymer of a water-insoluble monoolefinic monomer or (a) with 0 to 45% by weight of total monomers of a water-soluble monoolefinic monomer, with (b) 50 to 1% by weight, but not more than 20 mol % of a divinyl or polyvinyl crosslinking agent; and (B) an effective amount of a pharmaceutical medicament is useful for the controlled and prolonged release of drugs when taken orally.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.