3,7-Diazabicyclo(3,3,1)nonane compounds and their use in treating heart disease

US4550112A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Uwe Schoen · Burgdorf, DE
• Bernd Hachmeister · Hannover, DE
• Wolfgang Kehrbach · Hannover, DE
• Ulrich Kuehl · Hannover, DE
• Gerd Buschmann · Velbert, DE

Key dates

• Filing date: Sep 16, 1983
• Grant date: Oct 29, 1985
• Expiry date: Sep 16, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 3,7-diaza bicyclo-(3,3,1)-nonane compounds are described which are represented by the formula: ##STR1## wherein Z.sub.1 and Z.sub.2 each denotes hydrogen, PA0 R.sub.1 and R.sub.2 each denotes (A) a substituent which contains up to 12 carbon atoms and which is selected from the group consisting of alkyl, alkenyl, and alkinyl, or (B) a cycloalkyl group containing 3 to 6 carbon atoms which is attached to the nitrogen atom directly or by an alkylene group containing 1 to 3 carbon atoms, and PA0 R.sub.3 and R.sub.4 each denotes an alkyl group with up to 7 carbon atoms, or both together form an alkylene chain represented by the formula --(CH.sub.2).sub.n --, wherein n is an integer ranging between about 3 and 6, such that the substituents R.sub.1, R.sub.2, R.sub.3, and R.sub.4 together contain at least 5 carbon atoms. Also described are processes of producing said compounds, pharmaceutical compositions containing compounds of Formula I, and methods of preparing and using said compositions.