Certain piperidino-lower-alkylene esters of 3-methylflavone-8-carboxylates possessing smooth muscle relaxant activity

US4550115A · kind A · utility

Assignee

• Recordati S.A. Chemical and Pharmaceutical Company · CH

Inventors

• Dante Nardi · Milano, IT
• Alberto Tajana · Milano, IT
• Renzo Pennini · Milano, IT
• Pietro Cazzulani · Milano, IT
• Gabriele Graziani · Arese, IT
• Silvano Casadio · Milano, IT

Key dates

• Filing date: Jul 12, 1982
• Grant date: Oct 29, 1985
• Expiry date: Jul 12, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel 3-methylflavone-8-carboxylates having the structural formula (I): ##STR1## wherein Z is N-methylpiperidinyl, tropinyl or quinuclidinyl, or a group having the structural formula (II): ##STR2## in which n is 0 or 1, R is hydrogen or alkyl having from 1 to 4 carbon atoms, or phenyl, R.sub.1 is hydrogen or alkyl having from 1 to 4 carbon atoms, R.sub.2 is hydrogen or hydroxy, and further wherein R, R.sub.1 and R.sub.2 may together form, with the carbon atoms from which they depend, a cycloalkyl ring having from 4 to 6 carbon atoms, and R.sub.3 is hydrogen or alkyl having from 1 to 4 carbon atoms, with the proviso that R, R.sub.1, R.sub.2 and R.sub.3 cannot at the same time all be hydrogen, and the pharmaceutically acceptable salts thereof, are effective smooth muscle relaxants, calcium blockers, anaesthetics and anti-inflammatories.