Anthracycline compounds

US4550159A · kind A · utility

Assignee

• MICROBIAL CHEMISTRY RESEARCH FOUNDATION · JP

Inventors

• Hamao Umezawa · Tokyo, JP
• Tomio Takeuchi · Tokyo, JP
• Masa Hamada · Hoya, DE
• Hiroshi Naganawa · Tokyo, JP
• Tsutomu Sawa · Ayase, JP
• Takeshi Uchida · Takasaki, JP
• Masaya Imoto · Saitama, JP

Key dates

• Filing date: Oct 25, 1983
• Grant date: Oct 29, 1985
• Expiry date: Oct 25, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/465
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

An anthracycline compound, ditrisarubicin, of the formula: ##STR1## wherein R represents one of the following substituents (A), (B), and (C): ##STR2## is produced by a process which comprises cultivating a strain of Streptomyces in a suitable culture medium under aerobic conditions, said strain having the ability to produce the anthracycline compound, ditrisarubicin, and then recovering the anthracycline compound, ditrisarubicin, from the cultured medium. This ditrisarubicin, or an acid addition salt of the ditrisarubicin, can be contained as the active ingredient in antitumor agents and in pharmaceutical compositions for treatment of infections induced by gram-positive microorganisms, whereby good results are attainable.