Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides
US4551459A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 13, 1984 |
| Grant date | Nov 5, 1985 |
| Priority date | — |
| Expiry date | Apr 13, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds according to the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein: n is an integer of 1 to 6; PA1 R.sub.1 is hydrogen or alkyl of 1 to 4 carbon; PA1 R.sub.2 is hydrogen or R.sub.1 and R.sub.2 combined are oxo; PA1 R.sub.3 is hydrogen, alkyl of 1 to 6 carbons, phenyl, benzyl, hydroxy lower alkyl and its acylates, carbamoyl alkyl, carboxyalkyl, alkoxycarbonylalkyl or amino acid side chains; PA1 R.sub.4 is hydrogen, alkyl of 1 to 6 carbons, benzyl, or hydroxy lower alkyl; PA1 Y is hydrogen, alkyl of 1 to 4 carbon atoms, halo or lower alkoxy; PA1 A is an amide forming group wherein the nitrogen substituents are: hydrogen; alkyl of 1 to 6 carbon atoms; hydroxyalkyl of 1 to 6 carbon atoms and its aliphatic acylates of 1 to 6 carbon atoms or aryl acylates of 7 to 12 carbon atoms; cycloalkyl of 3 to 8 carbon atoms or cycloalkyl lower alkyl of 4 to 12 carbon atoms wherein the cycloalkyl ring is unsubstituted or substituted with a lower alkyl, lower alkoxy, --OH, --OCOR.sub.5, halo, --NH.sub.2, --N(R.sub.5).sub.2, --NHCOR.sub.5, --COOH, or --COO(R.sub.5) group wherein R.sub.5 is lower alkyl; phenyl or phenyl lower alkyl wherein phenyl is unsu…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.