Eburnane derivatives, process for their preparation and pharmaceutical compositions containing them
US4551462A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 27, 1983 |
| Grant date | Nov 5, 1985 |
| Priority date | — |
| Expiry date | Jun 27, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to racemic or optically active eburnane derivatives of the formula (I), ##STR1## wherein R represents an alkyl group having 1 to 6 carbon atoms, PA1 A stands for hydroxyl and PA1 Y is hydrogen, or PA1 A and Y together form an oxo group, PA1 and the configuration of the hydrogen in the 3-position and of R is .alpha.,.alpha. and/or .beta.,.beta. or .alpha.,.beta. and/or .beta.,.alpha., and acid addition salts thereof. The new compounds possess valuable pharmaceutical properties, thus their certain representatives show antiallergic activity, while others are potent antidepressive, gastric secretion inhibiting and anticonvulsive agents. The compounds of the formula (I) and pharmaceutically acceptable acid addition salts thereof can therefore be employed as active ingredients of pharmaceutical compositions, which are also within the scope of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.