Guanine-N.sup.7 -oxide
US4551529A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 1983 |
| Grant date | Nov 5, 1985 |
| Priority date | — |
| Expiry date | Oct 6, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/826
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A purified isolate of an actinomycete identified as ATCC 39364 is capable of producing the antimicrobial/antitumor compound 2-amino-1,9-dihydro-6H-purine-6-one-7-oxide, commonly known as guanine-N.sup.7 -oxide. Guanine-N.sup.7 -oxide is produced by cultivating isolate ATCC 39364 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of the compound is produced and thereafter isolating the compound. The antibiotic/antitumor compound guanine-N.sup.7 -oxide and pharmaceutical compositions comprising this compound or one of its pharmaceutically acceptable salts together with a pharmaceutically acceptable carrier are also disclosed as is a method of treating microbial infections in a mammal or of treating tumors in a mammal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.