Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
US4551542A · kind A · utility
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6References
11Claims
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Key dates
| Filing date | Sep 26, 1984 |
| Grant date | Nov 5, 1985 |
| Priority date | — |
| Expiry date | Sep 26, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/68
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
6-Fluoro-4-chromanone can be regenerated from (R)-6-fluoro-4-ureidochroman-4-carboxylic acid, or from mixtures of (R)-6-fluoro-4-ureidochroman-4-carboxylic acid and its racemic modification, by oxidation with a permanganate, especially potassium permanganate. 6-Fluoro-4-chromanone is a chemical intermediate useful for preparing sorbinil, an aldose reductase inhibitor which can be used in clinical medicine for the control of the chronic complications of diabetes. (R)-6-Fluoro-4-ureidochroman-4-carboxylic acid and its racemic modification are by-products from the production of sorbinil from 6-fluoro-4-chromanone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.