N.sub.b -Quaternary derivatives of sandwicine and isosandwicine methods and intermediate products in the manufacture of their derivatives and methods of using same and pharmaceutical compositions thereof

US4552877A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Wolfgang Kehrbach · Hannover, DE
• Joachim Wegener
• Ulrich Kuehl · Hannover, DE
• Renke Budden · Hannover, DE
• Gerd Buschmann · Velbert, DE

Key dates

• Filing date: May 31, 1984
• Grant date: Nov 12, 1985
• Expiry date: May 31, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New N.sub.b -quaternary 10-bromosandwicine and 10-bromoisosandwicine derivatives are disclosed which exhibit antiarrhythmic properties and adrenolytic properties and which have the formula I ##STR1## wherein R represents a carbon-attached organic group containing 1 to 10 carbon atoms and A.sup..crclbar. represents an acid anion, as well as pharmaceutical formulations thereof and processes and intermediates for their preparation.