Concentrating nikkomicin mixtures

US4552954A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Heinrich F. Moeschler · Leverkusen, DE
• Christian Golker · Wuppertal, DE
• Peter M. Lange · Leverkusen, DE

Key dates

• Filing date: May 26, 1983
• Grant date: Nov 12, 1985
• Expiry date: May 26, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P19/385
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for concentrating nikkomicins (X) and (Z) from a dilute impure aqueous solution thereof, comprising contacting the solution with a weakly basic ion exchanger and eluting the adsorbed material with an acid thereby to obtain a concentrated mixture of nikkomicin (X) and nikkomicin (Z). The dilute solution being treated can directly be a filtered microbial cultivation liquor or such a liquor can be prepurified by contact with an acid ion exchanger followed by elution with a base. The recovered material is of relatively high purity.