Method for production of imidazolyl vinyl ethers
US4554356A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 16, 1985 |
| Grant date | Nov 19, 1985 |
| Priority date | — |
| Expiry date | Jan 16, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the manufacture of imidazolylvinyl ethers of the formula ##STR1## wherein Im represents the substituted or unsubstituted 1-H-imidazol-1-yl group and An, R and Y are defined hereinbelow by condensation of a corresponding ketone of the formula EQU Ar--CO--CHR--Im (II) with the splitting-off of a Z group, with a condensable substance of the formula EQU Z--Y (III) in the aqueous solution of a strong inorganic base, preferably in concentrated aqueous soda lye. The reaction may also be carried out in the presence of a second liquid organic phase, preferably benzene or toluene, especially in the presence of a phase transfer catalyst in this case. Through careful crystallization of the product manufactured according to this method, it is possible to manufacture approximately pure E-isomers of the imidazolylvinyl ether of formula (I), without the requirement of chromatographic separation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.