Circulation-active novel chromone- and thiochromone-substituted 1,4-dihydropyridine-lactones

US4555512A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Siegfried Goldmann · Wuppertal, DE
• Friedrich Bossert
• Matthias Schramm · Cologne, DE
• Gunter Thomas · Arese, IT
• Rainer Gross · Wuppertal, DE

Key dates

• Filing date: Mar 14, 1984
• Grant date: Nov 26, 1985
• Expiry date: Mar 14, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/0812
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.5 and R.sup.6 can be hydrogen or various halogen or organic radicals, PA0 R.sup.4 is an optionally substituted hydrocarbon radical, PA0 A is a direct bond, a C.sub.1 -C.sub.20 -alkylene chain or a C.sub.2 -C.sub.20 -alkenylene chain, which chains are optionally interrupted by O or S PA0 X is O or S, and PA0 Y is a direct bond, O, S, --NH--or--N-alkyl with 1 to 8 C atoms PA0 or a pharmaceutically acceptable salt, are useful as cardiotonic agents for improving heart contractility, antihypotonic agents, for lowering the blood sugar level, for detumescing mucous membranes and for influencing the salt and/or liquid balance.