7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment of thrombolytic disease
US4555523A · kind A · utility
8Cited by
5References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 4, 1984 |
| Grant date | Nov 26, 1985 |
| Priority date | — |
| Expiry date | Jun 4, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl or alkali metal, R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl, X is O, S or NH, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2, p is 0 to 4, n is 1 to 4, n' is 0 to 2, q is 1 to 4 and m is 0 to 8, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease; and are antiinflammatory agents useful, for example, in the treatment of rheumatoid arthritis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.