Patent · US Expired

10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compositions thereof, and methods of treating heart rhythm disorders with them

US4558052A · kind A · utility

0Cited by

0References

5Claims

0Family size

Assignee

Kali-Chemie Pharma GmbH · DE

Inventors

Wolfgang Kehrbach · Hannover, DE
Joachim Wegener

Key dates

Filing date	Jun 8, 1984
Grant date	Dec 10, 1985
Priority date	—
Expiry date	Jun 8, 2004

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P9/06
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. There novel compounds possess valuable pharmacological properties e.g. heart rhythm regulatory properties. Furthermore they are valuable intermediates for the preparation of 10-brominated N.sub.b -quaternary sandwicine derivatives which exhibit heart rhythm regulatory and adrenolytic properties. 10-bromosandwicine is prepared by brominating sandwicine and can subsequently be isomerized into 10-bromoisosandwicine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.