Methods for detecting and imaging a temperature of an object by nuclear magnetic resonance
US4558279A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Mar 7, 1983 |
| Grant date | Dec 10, 1985 |
| Priority date | — |
| Expiry date | Mar 7, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel and improved method to detect indirectly a temperature of an object employing nuclear magnetic resonance techniques (NMR). The method involves obtaining an NMR spectrum to determine chemical shift, relaxation times, spin-spin couplings or quadrupole couplings for an element of a compound having at least one conformational isomer wherein the compound is influenced by a temperature of the object. Uniquely, the present invention may detect temperature in the body of an animal. Further, the present invention discloses a novel method to determine and monitor thermal physiological states in an animal as well as determine and monitor thermal states in an object. Because of the unique and advantageous non-invasive, non-destructive and non-ionizing properties, the present invention may be employed in an object or animal continuously. The present invention also provides for the thermal imaging, or NMR thermography, by one-, two-, or three-dimensional reconstruction techniques from chemical shift, relaxation times, (e.g., T.sub.1 or T.sub.2,) spin-spin couplings and quadrupole couplings for an element of a compound having at least one conformational isomer in an object or animal influ…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.