7.alpha.-Substituted 3-oxo-17.alpha.-pregn-4-ene-21,17-carbolactones, process for their production, and pharmaceutical preparations containing same

US4559331A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Klaus Nickisch · Berlin, DE
• Henry Laurent
• Peter Esperling · Berlin, DE
• Dieter Bittler · Berlin, DE
• Rudolf Wiechert · Berlin, DE
• Wolfgang Losert

Key dates

• Filing date: Aug 17, 1984
• Grant date: Dec 17, 1985
• Expiry date: Aug 17, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J53/008
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 7.alpha.-substituted 3-oxo-17.alpha.-pregn-4-ene-21,17-carbolactones of the formula ##STR1## wherein ##STR2## is a CC single or CC double bond or the group ##STR3## R.sup.7 is the group SR', R' being a hydrogen atom or a straight-chain or branched alkyl residue of 1-6 carbon atoms optionally substituted by a hydroxy or acyloxy group, the group COOR" or the group COR" wherein R" is an alkyl group of 1-4 carbon atoms and ##STR4## is a CC single bond or the group ##STR5## have antialdosterone activity with reduced endocrinological side effects.