Pyridine-pyrimidinone derivatives, a process for their production and H.sub. -antagonist medicament containing these compounds

US4559344A · kind A · utility

Assignee

• Ludwig Heumann & Co. GmbH · DE

Inventors

• Helmut Schickaneder · Eckental, DE
• Peter Morsdorf · Langenzenn, DE
• Stefan Postius · Konstanz, DE
• Istvan Szelenyi · Arnstorf, DE
• Rolf Herter · Schwabach, DE
• Herbert Hansen · Düsseldorf, DE
• Kurt H. Ahrens · Nürnberg, DE

Key dates

• Filing date: Jan 26, 1984
• Grant date: Dec 17, 1985
• Expiry date: Jan 26, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new pyridine-pyrimidinone derivatives corresponding to the following general formula ##STR1## wherein R.sup.1 represents linear C.sub.1-6 alkyl or cycloalkyl and R.sup.2 represents linear C.sub.1-6 alkyl or R.sup.1 and R.sup.2 together with the nitrogen atom form a pyrrolidine or piperidine ring; PA1 Alk represents a linear alkylene chain C.sub.1-6 ; PA1 Q represents a benzene ring, furan ring, thiophene ring or thiazole ring; PA1 X represents oxygen, Y is a single bond and m is 2, 3 or 4 when Q represents benzene; PA1 X represents methylene, Y represents sulfur and m is 2 or 3 when Q is furan, thiophene or thiazole; and PA1 R.sup.3 represents a hydrogen atom or a lower alkyl group. These compounds show improved H.sub.2 -antagonistic activity.