Method of relieving pain and inflammatory conditions employing substituted salicylamides
US4560549A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 24, 1983 |
| Grant date | Dec 24, 1985 |
| Priority date | — |
| Expiry date | Aug 24, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/41
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A topically and systemically administered anti-inflammatory composition for human and for veterinary consumption which comprises compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are defined hydrocarbon attachments and Y is --OH or a phenolic ester group derived from the reaction of such --OH group with a carboxylic acid halide or anhydride. In typical compounds covered by said general formula PA0 (a) R.sub.1 is H, R.sub.2 is 5,n-octanoyl, Y is hydroxy and R.sub.3 is p-trifluoromethylphenyl; PA0 (b) R.sub.1 is H, R.sub.2 is 5,n-decanoyl, Y is hydroxy and R.sub.3 is benzothiazol-2-yl and PA0 (c) R.sub.1 is H, R.sub.2 is 5,n-decanoyl, Y is acryloyloxy and R.sub.3 is p-nitrophenyl. The resulting compositions take the form of ointments, solid sticks, tablets, capsules, injectable solutions and suspensions, ear drops, eye drops, nose drops, douches, suppositories, enemas, liniments, gels, lotions, shampoos, soaps, creams, solutions, aerosols, pads, plasters, bandages, dressings and catamenial and non-catamenial tampons. The compositions are useful in relieving pain or inflammation as well as microbial infections in mammals when applied topically to the skin…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.