2-Piperazino-pteridines useful as antithrombotics and antimetastatics

US4560685A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Josef Roch · Biberach, DE
• Josef Nickl
• Erich Muller · Zell am Harmersbach, DE
• Berthold Narr · Biberach, DE
• Johannes Weisenberger · Biberach, DE
• Rainer Zimmermann · Mittelbiberach, DE
• Walter Haarmann

Key dates

• Filing date: Jun 18, 1984
• Grant date: Dec 24, 1985
• Expiry date: Jun 18, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D475/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is phenylalkylamino, alkylamino, dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino; PA1 R.sub.2 is dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino; and PA1 R.sub.3 is halogen, alkoxy, alkylthio, phenylalkoxy or phenylalkylthio; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antithrombotics and antimetastatics.