Two-phase formulation

US4562069A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ahmed Hegasy · Leverkusen, DE
• Roland Rupp · Bensberg, DE
• Klaus-Dieter Ramsch · Wuppertal, DE
• Helmut Luchtenberg · Niederkassel, DE

Key dates

• Filing date: May 2, 1984
• Grant date: Dec 31, 1985
• Expiry date: May 2, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/44
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In the treatment of cardiovascular and coronary disorders by administering to a patent suffering therefrom a solid preparation comprising nifedipine, the improvement which comprises administering such nifedipine in the form of a solid two-phase medicament formulation comprising a nifedipine coprecipitate, in which the nifedipine is present in a non-crystalline form, and crystalline nifedipine, whereby the nifedipine rapidly enters the blood stream in a relatively high concentration which is maintained for a relatively long time.