N-Acyl hexahydroindole-2-carboxylic acids and anti-hypertensive use thereof

US4562202A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hansjorg Urbach · Kronberg, DE
• Rainer Henning · Tokyo, JP
• Volker Teetz · Hofheim, DE
• Hans Wissmann · Bad Soden am Taunus, DE
• Reinhard Becker · Wiesbaden, DE

Key dates

• Filing date: Mar 21, 1983
• Grant date: Dec 31, 1985
• Expiry date: Mar 21, 2003

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of the formula I ##STR1## in which n denotes 0 or 1, PA1 R denotes hydrogen, alkyl or aralkyl, R.sup.1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, which each can be substituted by alkyl, alkoxy or halogen, arylalkyl or aroylalkyl, both of which can be substituted in the aryl radical as defined in the aforegoing, a monocyclic or bicyclic sulfur or oxygen and/or nitrogen heterocyclic radical, or a side chain of a naturally occurring aminoacid, R.sup.2 denotes hydrogen, alkyl, alkenyl or arylalkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl, which is monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy or 3-indolyl, PA1 and their physiologically acceptable salts, processes for their preparation, agents containing these and their use as medicaments and also bicyclic amino acids as their intermediates and processes for their preparati…