Trans-.DELTA..sup.2 -prostaglandin D derivatives, process for their preparation and compositions containing them
US4562204A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 28, 1983 |
| Grant date | Dec 31, 1985 |
| Priority date | — |
| Expiry date | Jun 28, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C405/0033
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Trans-.DELTA..sup.2 -prostaglandin D derivatives of the formula: ##STR1## wherein [A] is a group of the formula: ##STR2## X is ethylene or cis-vinylene, C.sub.13 -C.sub.14 -C.sub.15 is: (i) a group of the formula: ##STR3## when [A] is a group of the formula (II) or (III), or (ii) a group of the formula: ##STR4## when [A] is a group of the formula (IV), R is hydrogen or alkyl, R.sup.1 is a single bond or alkylene, R.sup.2 is alkyl, cycloalkyl, phenyl or phenoxy, the double bonds between C.sub.2 -C.sub.3 and between C.sub.13 -C.sub.14 are both E, the double bond between C.sub.9 -C.sub.10 is Z and the double bonds between C.sub.12 -C.sub.13 and between C.sub.14 -C.sub.15 are E, Z or a mixture thereof, provided that when R.sup.1 is a single bond, R.sup.2 does not represent a substituted or unsubstituted phenoxy group, and cyclodextrin clathrates and non-toxic salts thereof, possess anti-tumor activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.