Synergistic radiation protective pharmaceutical compositions
US4563479A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 18, 1984 |
| Grant date | Jan 7, 1986 |
| Priority date | — |
| Expiry date | Jan 18, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/59
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to a synergistic radiation protective pharmaceutical composition comprising 50 to 350 parts by weight of aminoalkyl-thiol-derivatives of the general formula II ##STR1## wherein R.sup.3 stands for hydrogen, or carboxamidino PA0 R.sup.4 stands for hydrogen or carboxy, PA0 B represents hydrogen or carboxamidino with the restriction that at least two of R.sup.3, R.sup.4 and B stand for hydrogen-- or a pharmaceutically acceptable acid addition salt thereof, 0.2 to 2 parts by weight of .omega.-acylamino-alkane-derivative of the general formula ##STR2## wherein R.sup.1 stands for hydrogen, C.sub.1-4 alkanoyl, aroyl or aryl-(C.sub.1-4)-alkoxy-carbonyl, PA0 R.sup.2 stands for hydrogen, or carboxy optionally esterified by C.sub.1-4 alkoxy or aryl-(C.sub.1-4)alkoxy, PA0 A stands for --SO.sub.2 OH or --O--PO(OH).sub.2, PA0 n stands for 1, 2 or 3 and PA0 m stands for 2, 3 or 4--or a pharmaceutically acceptable salt thereof, and pharmaceutically acceptable carriers, diluents and/or solvents, and/or other formulating excipients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.