Process for the preparation of 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide and its non-toxic salts

US4563521A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Karl Clauss · Hofheim, DE
• Adolf Linkies · Frankfurt, DE
• Dieter Reuschling · Rockenberg, DE

Key dates

• Filing date: Mar 20, 1985
• Grant date: Jan 7, 1986
• Expiry date: Mar 20, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D291/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide is prepared by reaction of acetoacetamide with at least approximately twice the molar amount of SO.sub.3 per mole of acetoacetamide, if appropriate in an inert inorganic or organic solvent. Relevant salts can be obtained, using bases, from the product which results in the form of the acid. The non-toxic salts, in particular the potassium salt, are valuable synthetic sweeteners.