Di-enzymatic chewable dentifrice
US4564519A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 8, 1983 |
| Grant date | Jan 14, 1986 |
| Priority date | — |
| Expiry date | Dec 8, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K8/66
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A di-enzymatic chewable dentifrice is provided which contains an oxidizable substrate and an oxidoreductase enzyme specific to such substrate for producing hydrogen peroxide upon chewing of the dentifrice and further contains a thiocyanate salt and lactoperoxidase for interacting with hydrogen peroxide to produce a hypothiocyanate bacterial inhibitor. The concentration of lactoperoxidase is at least about 2% of the concentration of the oxidoreductase enzyme, in International Units, to thereby limit the ratio of hydrogen peroxide to lactoperoxidase during oral chewing of the dentifrice. An illustrative enzymatic system for this purpose contains glucose, glucose oxidase, potassium thiocyanate and lactoperoxidase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.