Pyridoindole derivatives, compositions and use

US4564613A · kind A · utility

Assignee

• Troponwerke GmbH & Co. KG · DE

Inventors

• Karl-Heinz Boltze · Borod, DE
• Margaret A. Davies · Cologne, DE
• Bodo Junge · Wuppertal, DE
• Teunis Schuurman · Overath, DE
• Jorg Traber · Lohmar, DE

Key dates

• Filing date: Sep 14, 1984
• Grant date: Jan 14, 1986
• Expiry date: Sep 14, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyridoindoles of the formula ##STR1## in which R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 -alkyl, which is optionally substituted by the radical ##STR2## R.sub.2 and R.sub.3 represent H or form a bond, or R.sub.1 and R.sub.2 together represent O, --O--CH.sub.2 --CH.sub.2 --O-- or --S--CH.sub.2 --CH.sub.2 --S--, PA1 R.sub.4 represents H or the ##STR3## or R.sub.3 and R.sub.4 represent O, or PA1 R.sub.1 and R.sub.4 are members of an N-containing six-membered ring and PA1 R.sub.8 and R.sub.9 represent H or C.sub.1 -C.sub.4 -alkyl, or optionally form, with the N atom, a heterocyclic 5-membered or 6-membered ring, which can optionally also contain a further hetero-atom from the series comprising N, O or S, PA1 R.sub.5 represents H, C.sub.1 -C.sub.4 -alkyl or the group ##STR4## or R.sub.5 and R.sub.3 form a bond, and PA1 R.sub.10 and R.sub.11 represent C.sub.1 -C.sub.4 -alkyl or are members of an N-containing 5-membered or 6-membered ring, PA1 R.sub.6 represents H or C.sub.1 -C.sub.4 -alkyl and PA1 R.sub.7 represents halogen, or acid addition salts thereof, which are active on the central nervous system. Novel intermediates are also shown.