8-(Substituted N-phenylcarboxamidomethyl) pyrrolizidines and use thereof as antiarrhythmics
US4564624A · kind A · utility
5Cited by
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8Claims
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Key dates
| Filing date | Mar 10, 1983 |
| Grant date | Jan 14, 1986 |
| Priority date | — |
| Expiry date | Mar 10, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An 8-substituted pyrrolizidine derivative representable by the formula: ##STR1## (wherein R.sup.1 stands for hydrogen or a lower alkyl group, R.sup.2 stands for hydrogen, a lower alkyl group, a lower alkoxy group or halogen, and R.sup.3 stand for a lower alkyl group, a lower alkoxy group, amino group or halogen), which can be produced by reacting a corresponding substituted anilin with 8-halocarbonylmethyl pyrrolizidine or reacting an alkali metal salt of the corresponding substituted anilin with 8-alcoxycarbonylmethyl pyrrolizidine. The derivative is useful as an antiarrhythmic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.