Process for producing 4'-demethyl-epipodophyllotoxin-.beta.-D-ethylidene-glucoside and acyl-derivative thereof
US4564675A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 6, 1983 |
| Grant date | Jan 14, 1986 |
| Priority date | — |
| Expiry date | Sep 6, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein are a process for producing 4'-demethyl-epipodophyllotoxin-.beta.-D-ethylidene-glucoside of the formula (II) comprising (A) reacting 4'-halogenoacetyl-4'-demethyl-epipodophyllotoxin-.beta.-D-2,3-di-O-halogen oacetyl-4,6-O-ethylidene-glucoside of the formula (I) with an amine and/or ammonia, or (B) subjecting the acyl-derivative (I) to alcoholysis in the presence of a catalyst, thereby removing the halogenoacetyl groups of the acyl-derivative (I) to obtain the compound (II), the acyl-derivative (I), and the use of the acyl-derivative (I) for synthesizing the compound (II) ##STR1## wherein R represents a halogenoacetyl group represented by the formula EQU --COCH.sub.2 X wherein X is a halogen atom.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.