Certain nitratoalkyl ester dihydropyridines having antihypertensive properties

US4565824A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Egbert Wehinger
• Horst Meyer
• Stanislav Kazda · Wuppertal, DE
• Andreas Knorr · Erkrath, DE

Key dates

• Filing date: Nov 9, 1983
• Grant date: Jan 21, 1986
• Expiry date: Nov 9, 2003

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Dihydropyridines of the formula ##STR1## in which R is aryl or heterocyclic, PA1 R.sup.1, R.sup.2 and R.sup.3 each is hydrogen or various organic radicals, PA1 Y is oxygen, or optionally substituted --NH--, PA1 Z is --O--NO.sub.2 or --O--NO, PA1 X is --COR.sup.4, --COOR.sup.5 or --CO--Y--A--Z, PA1 R.sup.4 is alkyl, phenyl, benzyl or an amino radical, and PA1 R.sup.5 is an organic radical, or pharmaceutically acceptable acid addition salts thereof, exhibit circulation active properties, e.g. they can be used as antihypertensives, as peripheral and cerebral vasodilators and as coronary therapeutics.