Serirubicum

US4565861A · kind A · utility

Assignee

• MICROBIAL CHEMISTRY RESEARCH FOUNDATION · JP

Inventors

• Hamao Umezawa · Tokyo, JP
• Tomio Takeuchi · Tokyo, JP
• Masa Hamada · Hoya, DE
• Hiroshi Naganawa · Tokyo, JP
• Tsutomu Sawa · Ayase, JP
• Takeshi Uchida · Takasaki, JP
• Masaya Imoto · Saitama, JP

Key dates

• Filing date: Jan 3, 1984
• Grant date: Jan 21, 1986
• Expiry date: Jan 3, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/465
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

An anthracycline, serirubicin, of the formula: ##STR1## wherein R represents the substituent: ##STR2## is produced by a process which comprises cultivating a strain of Streptomyces in a suitable culture medium under aerobic conditions, said strain having the ability to produce the anthracycline compound, serirubicin, and then recovering the anthracycline compound, serirubicin, from the cultured medium. This serirubicin, or an acid addition salt of the serirubicin, can be contained as the active ingredient in anti-tumor agents and in pharmaceutical compositions for treatment of infections induced by gram-positive microorganisms, whereby good results are attainable.