Liquid active ingredient concentrates for preparation of microemulsions

US4567161A · kind A · utility

Assignee

• A. Natterman & Cie GmbH · DE

Inventors

• Ulrich Posanski · Glückstadt, DE
• Miklos Ghyczy · Cologne, DE
• Kurt Bauer
• Armin Wendel · Cologne, DE

Key dates

• Filing date: Jun 28, 1983
• Grant date: Jan 28, 1986
• Expiry date: Jun 28, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09K23/017
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Liquid, active substance formulations containing an active substance insoluble or poorly soluble in water, or a mixture, a phospholipid, a special co-emulsifier (glycerinester in which the 1 or 2 OH groups have been esterized with hydrocarbon atoms of 8-16, preferably 8-10, C atoms by means of fatty acids and the 3 or remaining OH group of the glycerin body has been etherized with polyethyleneglycol, specifically, with 6-30, preferably 6-15 ethyleneoxide units) and a liquid carrier, the molar ratio of phospholipid to co-emulsifier being from 1:1 to 1:4, and the formulations being such that when added to water they form a transparent liquid system in the form of a microemulsion, with a degree of fineness of 10-200 nm in the lipid phase.