Substituted 5,11-dihydro-6H-dibenz[b,e]azepin-6-ones and pharmaceutical compositions containing same

US4567178A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Wolfgang Eberlein · Biberach, DE
• Gunter Trummlitz · Warthausen, DE
• Wolfhard Engel
• Gunther Schmidt · Biberach, DE
• Rudolf Hammer · Ingelheim am Rhein, DE
• Antonio Giachetti · Marsala, IT

Key dates

• Filing date: Jan 7, 1985
• Grant date: Jan 28, 1986
• Expiry date: Jan 7, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel substituted 5,11-dihydro-6H-dibenz[b,e]azepin-6-one of the formula ##STR1## wherein A represents a (1-methyl-4-piperidinyl)-acetyl, (4-methyl-1-piperazinyl)-acetyl, or [(1-methyl-4-piperidinyl)-amino]-carbonyl group, and the acid addition salts thereof, which have valuable pharmacological properties, particularly an ulcer-inhibiting and secretion-inhibiting activity. The compounds of Formula I may be prepared using methods conventionally used for analogous compounds.